abstract：:The effect of glutathione co-therapy on the expression of gentamicin ototoxicity was tested in pigmented guinea pigs. The first group of animals was injected with gentamicin (100 mg/kg body weight/day) for two weeks followed by 10 weeks of rest. A second group received glutathione by gastric gavage immediately prior t...

journal_title：Hearing research

authors： Garetz SL,Altschuler RA,Schacht J

更新日期：1994-06-15 00:00:00

abstract：:Laser scanning confocal microscopy was used to determine the distribution of actin, spectrin and tubulin in whole mounts of the organ of Corti of guinea pig, monkey, rat and chinchilla. Actin, spectrin and tubulin were localized in all cell types in the auditory epithelium. No specialized cytoskeletal organization of ...

journal_title：Hearing research

authors： Raphael Y,Athey BD,Wang Y,Lee MK,Altschuler RA

更新日期：1994-06-01 00:00:00

abstract：:Several lines of evidence implicate a neurotransmitter/modulator role for ATP in the cochlea. Most of the work supporting such a notion has been accomplished using in vitro preparations of sensory hair cells or other cochlear tissues. Little is known regarding the functional consequences of ATP receptor activation in ...

journal_title：Hearing research

authors： Kujawa SG,Erostegui C,Fallon M,Crist J,Bobbin RP

更新日期：1994-06-01 00:00:00

abstract：:We show that trkB and trkC mRNAs, encoding the high-affinity receptor tyrosine kinases for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), respectively, as well as low-affinity nerve growth factor receptor (p75LNGFR) mRNA are expressed in the cochleovestibular ganglion (CVG) before and during inner...

journal_title：Hearing research

authors： Pirvola U,Arumäe U,Moshnyakov M,Palgi J,Saarma M,Ylikoski J

更新日期：1994-05-01 00:00:00

abstract：:It is generally believed that all bone surfaces are covered by a nearly continuous layer of cells known as bone lining cells (BLC) which separate the general extracellular fluid (GECF) from bone and its fluid compartment. Within the cochlea of some mammals regions of bone matrix are exposed to extracellular fluid. Wit...

journal_title：Hearing research

authors： Chole RA,Tinling SP

更新日期：1994-05-01 00:00:00

abstract：:The purpose of this study was to investigate the protective effects of U74389F (Upjohn Co. Kalamazoo, MI), a 21-aminosteroid/lipid peroxidation inhibitor, and a member of the lazaroid drug class, on temporary threshold shifts in animals exposed to prolonged noise stimulation. Animals treated with U74389F and exposed t...

journal_title：Hearing research

authors： Quirk WS,Shivapuja BG,Schwimmer CL,Seidman MD

更新日期：1994-04-01 00:00:00

abstract：:The distribution of S-100-like immunoreactivity in mouse and hamster auditory and vestibular end organs was determined by the use of immunohistochemistry. Within the organ of Corti, the cytoplasm of cells of Deiter and Hensen were strongly immunoreactive. Inner hair cells and the peripheral processes and cell bodies o...

journal_title：Hearing research

authors： Foster JD,Drescher MJ,Hatfield JS,Drescher DG

更新日期：1994-04-01 00:00:00

abstract：:We report the results of behavioral studies in cats conducted first, to demonstrate the presence of a monaural mechanism for the enhancement of signal to noise; and then to examine the necessity or sufficiency of the acoustic striae for this mechanism. The results show that cats do indeed have a monaural mechanism for...

journal_title：Hearing research

authors： Masterton RB,Granger EM,Glendenning KK

更新日期：1994-03-01 00:00:00

abstract：:The human fetus in utero is hypoxic relative to the neonate due to differences between placental and pulmonary oxygenation. Comparable degrees of hypoxia induced in young and adult animals caused an elevation in hearing threshold of a sensorineural nature. It was hypothesised therefore that the human fetus may also ha...

journal_title：Hearing research

authors： Sohmer H,Goitein K,Freeman S

更新日期：1994-02-01 00:00:00

abstract：:Receptors which bind the neurotrophins NGF, BDNF, NT-3 and NT-4/5 were shown to be present in cochlear and vestibular ganglion cells during development, implying a neurotrophic role for these molecules in the inner ear. We have found by in situ hybridization that cochlear and vestibular sensory epithelial cells expres...

journal_title：Hearing research

authors： Schecterson LC,Bothwell M

更新日期：1994-02-01 00:00:00

abstract：:Differences between inner and outer hair cells in the cellular content of precipitable calcium were detected using a potassium pyroantimonate precipitation method and the electron spectroscopic imaging (ESI-) technique. The cytoplasm of the inner hair cells was scattered with a high number of calcium precipitates in a...

journal_title：Hearing research

authors： Maurer J,Heinrich UR,Mann W

更新日期：1994-01-01 00:00:00

abstract：:Units in the auditory cortex of cats respond to a large variety of stimuli: pure tones, AM- and FM-modulated signals, clicks, wideband noise, natural sounds, and more. However, no single family of sounds was found to be optimal (in the sense that oriented lines are optimal in the visual cortex). The search for optimal...

journal_title：Hearing research

authors： Nelken I,Prut Y,Vaadia E,Abeles M

更新日期：1994-01-01 00:00:00

abstract：:Reported are the results of analyses of three-channel Lissajous trajectories (3CLTs) of the auditory brain stem responses (ABRs) in a human subject in whom a focal lesion of the brain stem was caused by stereotactic radiosurgery, the 'gamma knife'. The surgery caused total destruction of the right inferior colliculus....

journal_title：Hearing research

authors： Durrant JD,Martin WH,Hirsch B,Schwegler J

更新日期：1994-01-01 00:00:00

abstract：:This study addressed the hypotheses that the growth of the level of distortion product otoacoustic emissions (LDP) with primary-tone level reflects the behavior of a third-order nonlinear polynomial system, and that two sources exist for these distortion products. The results indicated that the 2f1-f2 otoacoustic emis...

journal_title：Hearing research

authors： Popelka GR,Osterhammel PA,Nielsen LH,Rasmussen AN

更新日期：1993-12-01 00:00:00

abstract：:Actin mRNA was characterised in hair-cell enriched fractions of the chick basilar papilla, by means of the reverse-transcription polymerase chain reaction technique. Primers were directed against the 3' untranslated portions of the actin mRNAs. Evidence for beta-cytoplasmic and gamma-cytoplasmic actin mRNA was found; ...

journal_title：Hearing research

authors： Pickles JO

更新日期：1993-12-01 00:00:00

abstract：:The stimulus level and frequency dependence of the quadratic difference tone (QDT) measured as an otoacoustic emission in the ear canal has been investigated in the guinea pig and compared with simultaneously measured cubic difference tone (CDT) and with the round window electrical response. Acoustic QDT level tended ...

journal_title：Hearing research

authors： Brown AM

更新日期：1993-11-01 00:00:00

abstract：:Inhibition of sodium/potassium pumping by isolated goldfish hair cells led to a rapid gain of sodium and loss of potassium. Half-times for turnover were about 10 min, among the fastest of any cell type examined by electron-probe analysis. Pumping was inhibited by removal of extracellular potassium or by treatment with...

journal_title：Hearing research

authors： Mroz EA,Nissim KR,Lechene C

更新日期：1993-10-01 00:00:00

abstract：:The cytosolic pH (pHi) of transitional cells from the ampulla of the gerbil was measured micro-fluorometrically with the pH-sensitive dye 2',7'-bicarboxyethyl-5(6)-carboxyfluorescein (BCECF) to assess the possible contribution of a Na+/H+ exchanger to the regulation of pHi. All experiments were conducted in virtually ...

journal_title：Hearing research

authors： Wangemann P,Shiga N,Marcus DC

更新日期：1993-09-01 00:00:00

abstract：:Drugs of the salicylate family (aspirin-like drugs) are reversibly ototoxic. Electrophysiologic and ultrastructural evidence suggests an impairment of the sensory hair cells of the cochlea following salicylate treatment. In addition, since these drugs can cause vasoconstriction, the ototoxicity of salicylates may also...

journal_title：Hearing research

authors： Didier A,Miller JM,Nuttall AL

更新日期：1993-09-01 00:00:00

abstract：:Gaumond et al. [(1982) J. Neurophysiol. 48, 856-873] showed in the cat that a multiplicative-intensity model can generally account quite well for reduction of the probability of an auditory-nerve spike by another spike preceding it by 4 to 25 ms, and that for smaller separations there is also an increased latency of t...

journal_title：Hearing research

authors： Ronken DA,Bosch WR,Molnar CE

更新日期：1993-09-01 00:00:00

abstract：:Hearing sensitivity and the prevalence of spontaneous otoacoustic emissions show parallel ear and sex differences in humans. Here it is proposed that these lateral asymmetries and sex differences may all result from differences in the 'strength' of the efferent inhibition delivered to individual cochleas. Specifically...

journal_title：Hearing research

authors： McFadden D

更新日期：1993-08-01 00:00:00

abstract：:Efficient transduction by acousticolateralis organs requires that a stimulus force principally deflect hair bundles, rather than flex other structural elements. Hair bundles might therefore be expected to provide a large fraction of the impedence to shear motions of otolithic membranes and other accessory structures. ...

journal_title：Hearing research

authors： Benser ME,Issa NP,Hudspeth AJ

更新日期：1993-08-01 00:00:00

abstract：:The nature of age-related improvements in auditory sensitivity was explored by comparing behavioral and auditory brainstem response (ABR) thresholds in 3- and 6-month-old infants and in adults. Thresholds were estimated for tone pips at 1, 4, and 8 kHz, presented at a rate of 13.3/s. The time course of development of ...

journal_title：Hearing research

authors： Werner LA,Folsom RC,Mancl LR

更新日期：1993-06-01 00:00:00

abstract：:This study used immunocytochemical markers for various classes of glial cells to investigate the relationship between glial elements and microcysts in the gerbil auditory system at the light and electron microscopic level. Monoclonal antibodies S-100, GFAP and Rip were used on tissue from 3- and 12-month old animals a...

journal_title：Hearing research

authors： Czibulka A,Schwartz IR

更新日期：1993-05-01 00:00:00

abstract：:This report concerns the morphological features of otoconia removed from the inner ear of four amphibian species. Results from scanning electron microscopic examination are compared based on the site of origin. These results show that utricular otoconia have a mineral structure that mimics calcite, rather than the wid...

journal_title：Hearing research

authors： Pote KG,Ross MD

更新日期：1993-05-01 00:00:00

abstract：:The glycoconjugates in the cochlea of the guinea pig were studied by staining samples by the silver methenamine method as well as after periodic acid-Schiff (PAS) staining. Results obtained by the two methods were similar but not identical. The silver methenamine method was much better in terms of resolution. However,...

journal_title：Hearing research

authors： Kawamata S,Igarashi Y

更新日期：1993-05-01 00:00:00

abstract：:Synaptic bodies (SBs) associated with rings of synaptic vesicles and well-defined, pre- and post-synaptic membrane structures are indicators of maturity in most hair cell-afferent nerve junctions. The role of the SBs remains elusive despite several experiments showing that they may be involved in storage of neurotrans...

journal_title：Hearing research

authors： Guth P,Norris C,Fermin CD,Pantoja M

更新日期：1993-04-01 00:00:00

abstract：:A single-channel hydromechanical model of the human cochlea with nonlinear feedback on the membrane is introduced. The piezoelectric transducers for displacement measurement and force exertion on the membrane are constructed of PVF2 in the bimorph bending type. The passive response shows high-frequency slopes of about...

journal_title：Hearing research

authors： Lechner TP

更新日期：1993-04-01 00:00:00

abstract：:Recordings were made from 185 neurons in the primary auditory cortex of cats in the age range of 15 to 297 days. A comparison was made between the tuning for click repetition-rate and for amplitude modulation-frequency of a noise burst on the basis of temporal Modulation Transfer Functions (tMTF). 90 of the 185 units ...

journal_title：Hearing research

authors： Eggermont JJ

更新日期：1993-02-01 00:00:00

abstract：:Several studies have compared the frequency selectivity of waves I and V of the auditory brainstem response (ABR) in humans, however little is known about the frequency selectivity of the middle latency response (MLR). Simultaneous recordings of ABRs and MLRs to 60 dB peSPL 2000-Hz probe tones were obtained in the pre...

journal_title：Hearing research

authors： Mackersie C,Down KE,Stapells DR

更新日期：1993-02-01 00:00:00

abstract：:Progress in amino acid sequencing of two low-molecular weight acidic proteins of unknown function which are present at high concentrations in the organ of Corti is reported. These two proteins, provisionally termed OCP1 and OCP2, were originally demonstrated by two-dimensional polyacrylamide gel electrophoresis; their...

journal_title：Hearing research

authors： Thalmann I,Suzuki H,McCourt DW,Comegys TH,Thalmann R

更新日期：1993-01-01 00:00:00

abstract：:Responses were recorded from single, auditory nerve fibres in the anaesthetized cat. Acoustic stimuli consisted of two tones, one of which was at characteristic frequency (CF), the other (the suppressor) was at considerably lower frequency. Tones were presented in simultaneous and sequential configurations. For simult...

journal_title：Hearing research

authors： Hill KG,Geisler CD

更新日期：1992-12-01 00:00:00

abstract：:Middle-ear to basilar membrane (BM) velocity transfer functions are reported for seven locations in the hook region of a single cat cochlea. These transfer functions were recorded at high sound pressure levels in a linearized, or passive cochlea, and resemble those reported previously by Wilson and Evans (1983). They ...

journal_title：Hearing research

authors： Cooper NP,Rhode WS

更新日期：1992-11-01 00:00:00

abstract：:Forward maskers within two frequency-intensity domains are capable of decreasing (enhancing) CAP latency: one region flanks the low frequency tail, the other flanks the tip/high frequency slope regions of the latency tuning curve (TC). By contrast, amplitude enhancement typically does not flank the high frequency slop...

journal_title：Hearing research

authors： Price JM,Henry KR

更新日期：1992-11-01 00:00:00

abstract：:Can the vestibular periphery of warm-blooded vertebrates recover functionally from severe sensory hair cell loss? Recent findings in birds suggest a mechanism for recovery but in fact no direct functional evidence has been reported. We produced vestibular hair cell lesions using the ototoxic agent streptomycin sulfate...

journal_title：Hearing research

authors： Jones TA,Nelson RC

更新日期：1992-10-01 00:00:00

abstract：:The effects of several hours of continuous electrical stimulation in the cats' cochlear nucleus with chronically implanted activated iridium microelectrodes was investigated from the changes in the evoked response near the inferior colliculus and also by histologic evaluation of the stimulated tissue. The stimulating ...

journal_title：Hearing research

authors： McCreery DB,Yuen TG,Agnew WF,Bullara LA

更新日期：1992-09-01 00:00:00

abstract：:Unlike the organ of Corti in mammals, the avian basilar papilla has no distinct populations of hair cells. Instead, there is a continuous change between the extreme forms (tall hair cells = THC, and short hair cells = SHC). The hair-cell innervation pattern is complicated, there being no simple gradient between THC (m...

journal_title：Hearing research

authors： Fischer FP

更新日期：1992-08-01 00:00:00

abstract：:The present study presents an atlas of the effects of 10 kHz tone exposures of different levels and durations on cochlear hair cells and their stereocilia in the Syrian golden hamster. Animals were sound exposed while under anesthesia. The exposure conditions were varied over an intensity range of 90-129 dB SPL; at th...

journal_title：Hearing research

authors： Kaltenbach JA,Schmidt RN,Kaplan CR

更新日期：1992-07-01 00:00:00

abstract：:Inner hair cell (IHC) recordings were made from second turn of the guinea pig cochlea where characteristic frequencies are approximately 4000 Hz. In order to compare IHC responses with rate suppression measured in the auditory nerve, suppressors were introduced that produced little or no response in the hair cell. The...

journal_title：Hearing research

authors： Cheatham MA,Dallos P

更新日期：1992-06-01 00:00:00

abstract：:The spontaneous fluctuations of the intracellular voltage and the position of the sensory hairbundle were measured concurrently using intracellular microelectrodes and an optical differential micro interferometer. Magnitude and frequency distribution of the hair bundles' spontaneous motion suggest that it consists mos...

journal_title：Hearing research

authors： Denk W,Webb WW

更新日期：1992-06-01 00:00:00